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A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter

G-quadruplexes, non-canonical nucleic acid structures, act as silencers in the promoter regions of human genes; putative G-quadruplex forming sequences are also present in promoters of other mammals, yeasts and prokaryotes. Here we show that also the HIV-1 LTR promoter exploits G-quadruplex-mediated...

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Detalhes bibliográficos
Main Authors: Perrone, Rosalba, Nadai, Matteo, Frasson, Ilaria, Poe, Jerrod A., Butovskaya, Elena, Smithgall, Thomas E., Palumbo, Manlio, Palù, Giorgio, Richter, Sara N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791109/
https://ncbi.nlm.nih.gov/pubmed/23865750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400914r
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