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Understanding pathogenic single-nucleotide polymorphisms in multidomain proteins – studies of isolated domains are not enough
Studying the effects of pathogenic mutations is more complex in multidomain proteins when compared with single domains: mutations occurring at domain boundaries may have a large effect on a neighbouring domain that will not be detected in a single-domain system. To demonstrate this, we present a stu...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Blackwell Publishing Ltd
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3790955/ https://ncbi.nlm.nih.gov/pubmed/23241237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12094 |
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