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Understanding pathogenic single-nucleotide polymorphisms in multidomain proteins – studies of isolated domains are not enough

Studying the effects of pathogenic mutations is more complex in multidomain proteins when compared with single domains: mutations occurring at domain boundaries may have a large effect on a neighbouring domain that will not be detected in a single-domain system. To demonstrate this, we present a stu...

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Detalhes bibliográficos
Main Authors: Randles, Lucy G, Dawes, Gwen J S, Wensley, Beth G, Steward, Annette, Nickson, Adrian A, Clarke, Jane
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790955/
https://ncbi.nlm.nih.gov/pubmed/23241237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12094
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