NEK8 Links the ATR-regulated Replication Stress Response and S-phase CDK Activity to Renal Ciliopathies

Renal ciliopathies are a leading cause of kidney failure, but their exact etiology is poorly understood. NEK8/NPHP9 is a ciliary kinase associated with two renal ciliopathies in humans and mice, nephronophthisis (NPHP) and polycystic kidney disease. Here, we identify NEK8 as a key effector of the AT...

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Bibliographische Detailangaben
Hauptverfasser: Choi, Hyo Jei Claudia, Lin, Jia-Ren, Vannier, Jean-Baptiste, Slaats, Gisela G., Kile, Andrew C., Paulsen, Renee D., Manning, Danielle K., Beier, David R., Giles, Rachel H., Boulton, Simon J., Cimprich, Karlene A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790667/
https://ncbi.nlm.nih.gov/pubmed/23973373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.08.006
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