Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus

The zinc-finger protein Ikaros is a key player in T-cell development and a potent tumor suppressor in thymocytes. To understand the molecular basis of its function, we disabled Ikaros activity in vivo using a dominant negative Ikaros transgene (DN-IkTg). In DN-IkTg mice, T-cell development was sever...

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Bibliographic Details
Main Authors: Tinsley, Kevin W., Hong, Changwan, Luckey, Megan A., Park, Joo-Young, Kim, Grace Y., Yoon, Hee-won, Keller, Hilary R., Sacks, Andrew J., Feigenbaum, Lionel, Park, Jung-Hyun
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790506/
https://ncbi.nlm.nih.gov/pubmed/23908463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-472076
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