Activin A Suppresses Osteoblast Mineralization Capacity by Altering Extracellular Matrix (ECM) Composition and Impairing Matrix Vesicle (MV) Production

During bone formation, osteoblasts deposit an extracellular matrix (ECM) that is mineralized via a process involving production and secretion of highly specialized matrix vesicles (MVs). Activin A, a transforming growth factor-β (TGF-β) superfamily member, was previously shown to have inhibitory eff...

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Autors principals: Alves, Rodrigo D. A. M., Eijken, Marco, Bezstarosti, Karel, Demmers, Jeroen A. A., van Leeuwen, Johannes P. T. M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790298/
https://ncbi.nlm.nih.gov/pubmed/23781072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.024927
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