Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030)

BACKGROUND: The aging process is accompanied by physiological changes including reduced glomerular filtration and hepatic function, as well as changes in gastric secretions. To investigate what effect would aging have on the disposition of capecitabine and its metabolites, the pharmacokinetics betwe...

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Bibliografiske detaljer
Main Authors: Louie, S G, Ely, B, Lenz, H-J, Albain, K S, Gotay, C, Coleman, D, Raghavan, D, Shields, A F, Gold, P J, Blanke, C D
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Clinical Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790171/
https://ncbi.nlm.nih.gov/pubmed/24022189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.517
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