Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030)

BACKGROUND: The aging process is accompanied by physiological changes including reduced glomerular filtration and hepatic function, as well as changes in gastric secretions. To investigate what effect would aging have on the disposition of capecitabine and its metabolites, the pharmacokinetics betwe...

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Detalhes bibliográficos
Main Authors: Louie, S G, Ely, B, Lenz, H-J, Albain, K S, Gotay, C, Coleman, D, Raghavan, D, Shields, A F, Gold, P J, Blanke, C D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790171/
https://ncbi.nlm.nih.gov/pubmed/24022189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.517
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