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The ATP Costs and Time Required to Degrade Ubiquitinated Proteins by the 26 S Proteasome
The degradation of ubiquitinated proteins by 26 S proteasomes requires ATP hydrolysis. To investigate if the six proteasomal ATPases function independently or in a cyclic manner, as proposed recently, we used yeast mutants that prevent ATP binding to Rpt3, Rpt5, or Rpt6. Although proteasomes contain...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3790020/ https://ncbi.nlm.nih.gov/pubmed/23965995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482570 |
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