Autoimmunity against INS-IGF2 Protein Expressed in Human Pancreatic Islets

Insulin is a major autoantigen in islet autoimmunity and progression to type 1 diabetes. It has been suggested that the insulin B-chain may be critical to insulin autoimmunity in type 1 diabetes. INS-IGF2 consists of the preproinsulin signal peptide, the insulin B-chain, and eight amino acids of the...

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Main Authors: Kanatsuna, Norio, Taneera, Jalal, Vaziri-Sani, Fariba, Wierup, Nils, Larsson, Helena Elding, Delli, Ahmed, Skärstrand, Hanna, Balhuizen, Alexander, Bennet, Hedvig, Steiner, Donald F., Törn, Carina, Fex, Malin, Lernmark, Åke
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789998/
https://ncbi.nlm.nih.gov/pubmed/23935095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478222
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