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Pharmacokinetics of Levetiracetam in Neonates with Seizures

The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.

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Dades bibliogràfiques
Autors principals: Merhar, Stephanie L., Schibler, Kurt R., Sherwin, Catherine M., Meinzen-Derr, Jareen, Shi, Jing, Balmakund, Tonya, Vinks, Alexander A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789844/
https://ncbi.nlm.nih.gov/pubmed/21592494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2011.03.057
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