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Pharmacokinetics of Levetiracetam in Neonates with Seizures

The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.

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書誌詳細
主要な著者: Merhar, Stephanie L., Schibler, Kurt R., Sherwin, Catherine M., Meinzen-Derr, Jareen, Shi, Jing, Balmakund, Tonya, Vinks, Alexander A.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789844/
https://ncbi.nlm.nih.gov/pubmed/21592494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2011.03.057
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