Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection. We show that, early during development o...

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Bibliographic Details
Main Authors: Worthington, John J., Klementowicz, Joanna E., Rahman, Sayema, Czajkowska, Beata I., Smedley, Catherine, Waldmann, Herman, Sparwasser, Tim, Grencis, Richard K., Travis, Mark A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789784/
https://ncbi.nlm.nih.gov/pubmed/24098124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003675
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