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Accurate identification of polyadenylation sites from 3′ end deep sequencing using a naïve Bayes classifier

Motivation: 3′ end processing is important for transcription termination, mRNA stability and regulation of gene expression. To identify 3′ ends, most techniques use an oligo-dT primer to construct deep sequencing libraries. However, this approach can lead to identification of artifactual polyadenyla...

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Bibliografski detalji
Glavni autori: Sheppard, Sarah, Lawson, Nathan D., Zhu, Lihua Julie
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789547/
https://ncbi.nlm.nih.gov/pubmed/23962617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btt446
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