Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter

Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A. In humans, heme oxygenase-1 expression is modulated by polymorphisms in the promoter of the heme oxygenase-1-encoding gene (HM...

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Main Authors: Repessé, Yohann, Peyron, Ivan, Dimitrov, Jordan D, Dasgupta, Suryasarathi, Moshai, Elika Farrokhi, Costa, Catherine, Borel-Derlon, Annie, Guillet, Benoit, D’Oiron, Roseline, Aouba, Achille, Rothschild, Chantal, Oldenburg, Johannes, Pavlova, Anna, Kaveri, Srinivas V, Lacroix-Desmazes, Sébastien
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789472/
https://ncbi.nlm.nih.gov/pubmed/23716558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.084665
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