Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells

This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia. Polo-like kinase 1 protein and Thr210 phosphorylation levels were higher in...

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Autors principals: Hartsink-Segers, Stefanie A., Exalto, Carla, Allen, Matthew, Williamson, Daniel, Clifford, Steven C., Horstmann, Martin, Caron, Huib N., Pieters, Rob, Den Boer, Monique L.
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789458/
https://ncbi.nlm.nih.gov/pubmed/23753023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.084434
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