Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis

Oculoleptomeningeal amyloidosis (OA) is a fatal and untreatable hereditary disease characterized by the accumulation of transthyretin (TTR) amyloid within the central nervous system. The mechanisms underlying the pathogenesis of OA, and in particular how amyloid triggers neuronal damage, are still u...

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Détails bibliographiques
Auteurs principaux: Azevedo, E P, Ledo, J H, Barbosa, G, Sobrinho, M, Diniz, L, Fonseca, A C C, Gomes, F, Romão, L, Lima, F R S, Palhano, F L, Ferreira, S T, Foguel, D
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789183/
https://ncbi.nlm.nih.gov/pubmed/24008733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.325
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