A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

The importance of tissue transglutaminase (TG2) in angiogenesis is unclear and contradictory. Here we show that inhibition of extracellular TG2 protein crosslinking or downregulation of TG2 expression leads to inhibition of angiogenesis in cell culture, the aorta ring assay and in vivo models. In a...

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Detalhes bibliográficos
Main Authors: Wang, Z, Perez, M, Caja, S, Melino, G, Johnson, T S, Lindfors, K, Griffin, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789176/
https://ncbi.nlm.nih.gov/pubmed/24052076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.318
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