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Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration

CNS neurons, such as retinal ganglion cells (RGCs), do not normally regenerate injured axons, but instead undergo apoptotic cell death. Regenerative failure is due to inhibitory factors in the myelin and forming glial scar as well as due to an insufficient intrinsic capability of mature neurons to r...

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Detalhes bibliográficos
Main Authors: Leibinger, M, Andreadaki, A, Diekmann, H, Fischer, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789169/
https://ncbi.nlm.nih.gov/pubmed/24052073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.310
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