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DNA Damage Repair Genes Controlling Human Papillomavirus (HPV) Episome Levels under Conditions of Stability and Extreme Instability

DNA damage response (DDR) genes and pathways controlling the stability of HPV episomal DNA are reported here. We set out to understand the mechanism by which a DNA-binding, N-methylpyrrole-imidazole hairpin polyamide (PA25) acts to cause the dramatic loss of HPV DNA from cells. Southern blots reveal...

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Detalhes bibliográficos
Main Authors: Edwards, Terri G., Vidmar, Thomas J., Koeller, Kevin, Bashkin, James K., Fisher, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788802/
https://ncbi.nlm.nih.gov/pubmed/24098381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075406
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