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TGF-β1 Downregulates COX-2 Expression Leading to Decrease of PGE2 Production in Human Lung Cancer A549 Cells, Which Is Involved in Fibrotic Response to TGF-β1

Transforming growth factor-ß1 (TGF-β1) is a multifunctional cytokine that is involved in various pathophysiological processes, including cancer progression and fibrotic disorders. Here, we show that treatment with TGF-β1 (5 ng/mL) induced downregulation of cyclooxygenase-2 (COX-2), leading to reduce...

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Bibliografiske detaljer
Main Authors: Takai, Erina, Tsukimoto, Mitsutoshi, Kojima, Shuji
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788736/
https://ncbi.nlm.nih.gov/pubmed/24098479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076346
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