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Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-β through a PGE(2)-dependent mechanisms
Although it is well established that mammary tumorigenesis converts transforming growth factor-β (TGF-β) from a tumor suppressor to a tumor promoter, the molecular, cellular and microenvironmental mechanisms underlying the dichotomous nature of TGF-β in mammary epithelial cells (MECs) remains to be...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577139/ https://ncbi.nlm.nih.gov/pubmed/18725385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn202 |
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