Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-β through a PGE(2)-dependent mechanisms

Although it is well established that mammary tumorigenesis converts transforming growth factor-β (TGF-β) from a tumor suppressor to a tumor promoter, the molecular, cellular and microenvironmental mechanisms underlying the dichotomous nature of TGF-β in mammary epithelial cells (MECs) remains to be...

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Main Authors: Neil, Jason R., Johnson, Kyle M., Nemenoff, Raphael A., Schiemann, William P.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Carcinogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577139/
https://ncbi.nlm.nih.gov/pubmed/18725385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn202
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