Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection

The influenza M2 ectodomain (M2e) is poorly immunogenic and has some amino acid changes among isolates from different host species. We expressed a tandem repeat construct of heterologous M2e sequences (M2e5x) derived from human, swine, and avian origin influenza A viruses on virus-like particles (M2...

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Huvudupphovsmän: Kim, Min-Chul, Lee, Jong-Seok, Kwon, Young-Man, Eunju, O, Lee, Youn-Jeong, Choi, Jun-Gu, Wang, Bao-Zhong, Compans, Richard W., Kang, Sang-Moo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788098/
https://ncbi.nlm.nih.gov/pubmed/23811283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2013.06.010
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