7,8-Dihydroxyflavone Suppresses Oxidative Stress-Induced Base Modification in DNA via Induction of the Repair Enzyme 8-Oxoguanine DNA Glycosylase-1

The modified guanine base 8-oxoguanine (8-oxoG) is abundantly produced by oxidative stress, can contribute to carcinogenesis, and can be removed from DNA by 8-oxoguanine DNA glycosylase-1 (OGG1), which acts as an 8-oxoG glycosylase and endonuclease. This study investigated the mechanism by which 7,8...

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Detalhes bibliográficos
Main Authors: Kim, Ki Cheon, Lee, In Kyung, Kang, Kyoung Ah, Cha, Ji Won, Cho, Suk Ju, Na, Soo Young, Chae, Sungwook, Kim, Hye Sun, Kim, Suhkmann, Hyun, Jin Won
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787557/
https://ncbi.nlm.nih.gov/pubmed/24151624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/863720
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