Lentiviral Small Hairpin RNA Knockdown of Macrophage Inflammatory Protein-1γ Ameliorates Experimentally Induced Osteoarthritis in Mice

Immune cells are involved in the pathogenesis of osteoarthritis (OA). CD4(+) T cells were activated during the onset of OA and induced macrophage inflammatory protein (MIP)-1γ expression and subsequent osteoclast formation. We evaluated the effects of local knockdown of MIP-1γ in a mouse OA model in...

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Autori principali: Shen, Po-Chuan, Lu, Chia-Sing, Shiau, Ai-Li, Lee, Che-Hsin, Jou, I-Ming, Hsieh, Jeng-Long
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2013
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787402/
https://ncbi.nlm.nih.gov/pubmed/24016310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.189
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