Quantification of Swelling and Erosion in the Controlled Release of a Poorly Water-Soluble Drug Using Synchrotron X-ray Computed Microtomography

The hydration layer plays a key role in the controlled drug release of gel-forming matrix tablets. For poorly water-soluble drugs, matrix erosion is considered as the rate limiting step for drug release. However, few investigations have reported on the quantification of the relative importance of sw...

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Detalhes bibliográficos
Main Authors: Yin, Xianzhen, Li, Haiyan, Guo, Zhen, Wu, Li, Chen, Fangwei, de Matas, Marcel, Shao, Qun, Xiao, Tiqiao, York, Peter, He, You, Zhang, Jiwen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787229/
https://ncbi.nlm.nih.gov/pubmed/23861022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-013-9498-y
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