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Functionally Deregulated AML1/RUNX1 Cooperates with BCR-ABL to Induce a Blastic Phase-Like Phenotype of Chronic Myelogenous Leukemia in Mice

Patients in the chronic phase (CP) of chronic myelogenous leukemia (CML) have been treated successfully following the advent of ABL kinase inhibitors, but once they progress to the blast crisis (BC) phase the prognosis becomes dismal. Although mechanisms underlying the progression are largely unknow...

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Hlavní autoři: Yamamoto, Kiyoko, Tsuzuki, Shinobu, Minami, Yosuke, Yamamoto, Yukiya, Abe, Akihiro, Ohshima, Koichi, Seto, Masao, Naoe, Tomoki
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787010/
https://ncbi.nlm.nih.gov/pubmed/24098673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074864
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