Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A

OBJECTIVE: Interleukin (IL)-17A producing CD4 T-cells (T(H)-17 cells) are implicated in rheumatoid arthritis (RA). IL-6/STAT3 signalling drives T(H)-17 cell differentiation, and hyperactive gp130/STAT3 signalling in the gp130(F/F) mouse promotes exacerbated pathology. Conversely, STAT1-activating cy...

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Detalhes bibliográficos
Main Authors: Jones, G W, Greenhill, C J, Williams, J O, Nowell, M A, Williams, A S, Jenkins, B J, Jones, S A
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2013
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786637/
https://ncbi.nlm.nih.gov/pubmed/23894061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-203771
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