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The Use of Structural Biology In Janus Kinase Targeted Drug Discovery

The Janus kinases (or Jak kinases) mediate cytokine and growth factor signal transduction. Acquired or inherited Jak mutations can result in dysregulation of Jak-mediated signal transduction and can be critical to disease acquisition in neoplasias including acute myeloid, acute lymphoblastic and acu...

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Main Authors: Alicea Velázquez, Nilda L., Boggon, Titus J.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786457/
https://ncbi.nlm.nih.gov/pubmed/21126226
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