Selective induction of CTL ‘helper’ rather than killer activity by natural epitope variants promotes DC-mediated HIV-1 dissemination

The ability of HIV-1 to rapidly accumulate mutations provides the virus with an effective means of escaping CD8(+) cytotoxic T lymphocyte (CTL) responses. Here we describe how subtle alterations in CTL epitopes expressed by naturally occurring HIV-1 variants can result in an incomplete escape from C...

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Main Authors: Mailliard, Robbie B., Smith, Kellie N., Fecek, Ronald J., Rappocciolo, Giovanna, Nascimento, Eduardo J. M., Marques, Ernesto T., Watkins, Simon C., Mullins, James I., Rinaldo, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786204/
https://ncbi.nlm.nih.gov/pubmed/23913962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300373
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