Parthanatos Mediates AIMP2 Activated Age Dependent Dopaminergic Neuronal Loss

The defining pathogenic feature of Parkinson’s disease is the age dependent loss of dopaminergic neurons. Mutations and inactivation of parkin, an ubiquitin E3 ligase, cause Parkinson’s disease through accumulation of pathogenic substrates. Here we show that transgenic overexpression of the parkin s...

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Main Authors: Lee, Yunjong, Karuppagounder, Senthilkumar S., Shin, Joo-Ho, Lee, Yun-Il, Ko, Han Seok, Swing, Debbie, Jiang, Haisong, Kang, Sung-Ung, Lee, Byoung Dae, Kang, Ho Chul, Kim, Donghoon, Tessarollo, Lino, Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785563/
https://ncbi.nlm.nih.gov/pubmed/23974709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3500
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