Repeated Ketamine Exposure Induces an Enduring Resilient Phenotype in Adolescent and Adult Rats

BACKGROUND: Major Depressive Disorder (MDD) afflicts up to 10% of adolescents. However, nearly 50% of those afflicted are considered non-responsive to available treatments. Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist has shown potential as a rapid-acting and long-last...

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Main Authors: Parise, Eric M., Alcantara, Lyonna F., Warren, Brandon L., Wright, Katherine N., Hadad, Roey, Sial, Omar K., Kroeck, Kyle G., Iñiguez, Sergio D., Bolaños-Guzmán, Carlos A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785550/
https://ncbi.nlm.nih.gov/pubmed/23790225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.04.027
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