Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor–deficient mice

To clarify the physiological roles of histamine H2 receptor (H2R), we have generated histamine H2R-deficient mice by gene targeting. Homozygous mutant mice were viable and fertile without apparent abnormalities and, unexpectedly, showed normal basal gastric pH. However, the H2R-deficient mice exhibi...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Kobayashi, Takashi, Tonai, Shunsuke, Ishihara, Yasunobu, Koga, Ritsuko, Okabe, Susumu, Watanabe, Takeshi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2000
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC378512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10862789/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9441
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