IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion

Bone destruction is the most difficult target in the treatment of rheumatoid arthritis (RA). Here, we report that local overexpression of IL-4, introduced by a recombinant human type 5 adenovirus vector (Ad5E1mIL-4) prevents joint damage and bone erosion in the knees of mice with collagen arthritis...

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Autores principales: Lubberts, Erik, Joosten, Leo A.B., Chabaud, Martine, van den Bersselaar, Liduine, Oppers, Birgitte, Coenen-de Roo, Christina J.J., Richards, Carl D., Miossec, Pierre, van den Berg, Wim B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC378501/
https://ncbi.nlm.nih.gov/pubmed/10862785
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