IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion

Bone destruction is the most difficult target in the treatment of rheumatoid arthritis (RA). Here, we report that local overexpression of IL-4, introduced by a recombinant human type 5 adenovirus vector (Ad5E1mIL-4) prevents joint damage and bone erosion in the knees of mice with collagen arthritis...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lubberts, Erik, Joosten, Leo A.B., Chabaud, Martine, van den Bersselaar, Liduine, Oppers, Birgitte, Coenen-de Roo, Christina J.J., Richards, Carl D., Miossec, Pierre, van den Berg, Wim B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC378501/
https://ncbi.nlm.nih.gov/pubmed/10862785
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados