Activation of Protein Kinase C-Mitogen-activated Protein Kinase Signaling in Response to Inositol Starvation Triggers Sir2p-dependent Telomeric Silencing in Yeast

Depriving wild type yeast of inositol, a soluble precursor for phospholipid, phosphoinositide, and complex sphingolipid synthesis, activates the protein kinase C (PKC)-MAPK signaling pathway, which plays a key role in the activation of NAD(+)-dependent telomeric silencing. We now report that trigger...

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Detalhes bibliográficos
Main Authors: Lee, Sojin, Gaspar, Maria L., Aregullin, Manuel A., Jesch, Stephen A., Henry, Susan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784701/
https://ncbi.nlm.nih.gov/pubmed/23943620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.493072
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