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Zinc, insulin, and the liver: a ménage à trois
Insulin and Zn(2+) enjoy a multivalent relationship. Zn(2+) binds insulin in pancreatic β cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological signals such as increased blood glucose. This transition metal is an essential cofactor in ins...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784553/ https://ncbi.nlm.nih.gov/pubmed/24051373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72325 |
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