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Zinc, insulin, and the liver: a ménage à trois
Insulin and Zn(2+) enjoy a multivalent relationship. Zn(2+) binds insulin in pancreatic β cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological signals such as increased blood glucose. This transition metal is an essential cofactor in ins...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784553/ https://ncbi.nlm.nih.gov/pubmed/24051373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72325 |
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