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REEPing the benefits of an animal model of hereditary spastic paraplegia
The hereditary spastic paraplegias (HSPs) are characterized by spasticity of the leg muscles due to axonal degeneration of corticospinal neurons. Beetz et al. report that the core motor phenotype and axonal pathology of HSPs are recapitulated in mice lacking the HSP-associated gene Reep1. REEP1 is s...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784552/ https://ncbi.nlm.nih.gov/pubmed/24051371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72324 |
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