Exclusive CX(3)CR1 dependence of kidney DCs impacts glomerulonephritis progression

DCs and macrophages both express the chemokine receptor CX(3)CR1. Here we demonstrate that its ligand, CX(3)CL1, is highly expressed in the murine kidney and intestine. CX(3)CR1 deficiency markedly reduced DC numbers in the healthy and inflamed kidney cortex, and to a lesser degree in the kidney med...

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Autori principali: Hochheiser, Katharina, Heuser, Christoph, Krause, Torsten A., Teteris, Simon, Ilias, Anissa, Weisheit, Christina, Hoss, Florian, Tittel, André P., Knolle, Percy A., Panzer, Ulf, Engel, Daniel R., Tharaux, Pierre-Louis, Kurts, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784547/
https://ncbi.nlm.nih.gov/pubmed/23999431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70143
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