Exclusive CX(3)CR1 dependence of kidney DCs impacts glomerulonephritis progression

DCs and macrophages both express the chemokine receptor CX(3)CR1. Here we demonstrate that its ligand, CX(3)CL1, is highly expressed in the murine kidney and intestine. CX(3)CR1 deficiency markedly reduced DC numbers in the healthy and inflamed kidney cortex, and to a lesser degree in the kidney med...

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Hauptverfasser: Hochheiser, Katharina, Heuser, Christoph, Krause, Torsten A., Teteris, Simon, Ilias, Anissa, Weisheit, Christina, Hoss, Florian, Tittel, André P., Knolle, Percy A., Panzer, Ulf, Engel, Daniel R., Tharaux, Pierre-Louis, Kurts, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784547/
https://ncbi.nlm.nih.gov/pubmed/23999431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70143
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