Inhibiting glycolytic metabolism enhances CD8(+) T cell memory and antitumor function

Naive CD8(+) T cells rely upon oxidation of fatty acids as a primary source of energy. After antigen encounter, T cells shift to a glycolytic metabolism to sustain effector function. It is unclear, however, whether changes in glucose metabolism ultimately influence the ability of activated T cells t...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Sukumar, Madhusudhanan, Liu, Jie, Ji, Yun, Subramanian, Murugan, Crompton, Joseph G., Yu, Zhiya, Roychoudhuri, Rahul, Palmer, Douglas C., Muranski, Pawel, Karoly, Edward D., Mohney, Robert P., Klebanoff, Christopher A., Lal, Ashish, Finkel, Toren, Restifo, Nicholas P., Gattinoni, Luca
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784544/
https://ncbi.nlm.nih.gov/pubmed/24091329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69589
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi