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p16(INK4a) protects against dysfunctional telomere–induced ATR-dependent DNA damage responses
Dysfunctional telomeres limit cellular proliferative capacity by activating the p53-p21– and p16(INK4a)-Rb–dependent DNA damage responses (DDRs). The p16(INK4a) tumor suppressor accumulates in aging tissues, is a biomarker for cellular senescence, and limits stem cell function in vivo. While the act...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784543/ https://ncbi.nlm.nih.gov/pubmed/24091330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69574 |
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