Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

Myeloid-derived suppressor cells (MDSCs) comprise immature myeloid populations produced in diverse pathologies, including neoplasia. Because MDSCs can impair antitumor immunity, these cells have emerged as a significant barrier to cancer therapy. Although much research has focused on how MDSCs promo...

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Main Authors: Waight, Jeremy D., Netherby, Colleen, Hensen, Mary L., Miller, Austin, Hu, Qiang, Liu, Song, Bogner, Paul N., Farren, Matthew R., Lee, Kelvin P., Liu, Kebin, Abrams, Scott I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784535/
https://ncbi.nlm.nih.gov/pubmed/24091328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68189
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