Epithelial stem cell mutations that promote squamous cell carcinoma metastasis

Squamous cell carcinomas (SCCs) originate in stratified epithelia, with a small subset becoming metastatic. Epithelial stem cells are targets for driver mutations that give rise to SCCs, but it is unknown whether they contribute to oncogenic multipotency and metastasis. We developed a mouse model of...

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Detalhes bibliográficos
Main Authors: White, Ruth A., Neiman, Jill M., Reddi, Anand, Han, Gangwen, Birlea, Stanca, Mitra, Doyel, Dionne, Laikuan, Fernandez, Pam, Murao, Kazutoshi, Bian, Li, Keysar, Stephen B., Goldstein, Nathaniel B., Song, Ningjing, Bornstein, Sophia, Han, Zheyi, Lu, Xian, Wisell, Joshua, Li, Fulun, Song, John, Lu, Shi-Long, Jimeno, Antonio, Roop, Dennis R., Wang, Xiao-Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784525/
https://ncbi.nlm.nih.gov/pubmed/23999427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65856
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