Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance

Plasmacytoid dendritic cells (pDCs) express the I-type lectin receptor Siglec-H and produce interferon α (IFNα), a critical anti-viral cytokine during the acute phase of murine cytomegalovirus (MCMV) infection. The ligands and biological functions of Siglec-H still remain incompletely defined in viv...

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Detalhes bibliográficos
Main Authors: Puttur, Franz, Arnold-Schrauf, Catharina, Lahl, Katharina, Solmaz, Gulhas, Lindenberg, Marc, Mayer, Christian Thomas, Gohmert, Melanie, Swallow, Maxine, van Helt, Christopher, Schmitt, Heike, Nitschke, Lars, Lambrecht, Bart N., Lang, Roland, Messerle, Martin, Sparwasser, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784486/
https://ncbi.nlm.nih.gov/pubmed/24086137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003648
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