Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes

Indenoisoquinolines are the most promising non-campthotecins topoisomerase IB inhibitors. We present an integrated experimental/computational investigation of the UV-Vis spectra of the IQNs parental compound (NSC314622) and two of its derivatives (NSC724998 and NSC725776) currently undergoing Phase...

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Main Authors: Coletta, Andrea, Castelli, Silvia, Chillemi, Giovanni, Sanna, Nico, Cushman, Mark, Pommier, Yves, Desideri, Alessandro
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784438/
https://ncbi.nlm.nih.gov/pubmed/24086299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073881
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