The PI3K inhibitor GS-1101 synergistically potentiates HDAC inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and ERK pathways

Previously, we showed that inhibition of the protein kinase C β (PKCβ)/AKT pathway augments engagement of the histone deacetylase inhibitor (HDI)-induced apoptosis in lymphoma cells. In the present study, we investigated the cytotoxicity and mechanisms of cell death induced by the delta isoform-spec...

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Hlavní autoři: Bodo, Juraj, Zhao, Xiaoxian, Sharma, Arishya, Hill, Brian T., Portell, Craig A., Lannutti, Brian J., Almasan, Alexandru, Hsi, Eric D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784300/
https://ncbi.nlm.nih.gov/pubmed/23889282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12498
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