Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

The goal of this study was to determine whether the mechanical activation of mechanistic target of rapamycin (mTOR) signalling is associated with changes in phosphorylation of tuberous sclerosis complex-2 (TSC2) and targeting of mTOR and TSC2 to the lysosome. As a source of mechanical stimulation, m...

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Detalhes bibliográficos
Main Authors: Jacobs, Brittany L, You, Jae-Sung, Frey, John W, Goodman, Craig A, Gundermann, David M, Hornberger, Troy A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Skeletal Muscle and Exercise
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784202/
https://ncbi.nlm.nih.gov/pubmed/23732640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.256339
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