Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca(2+) release

Hypoxic pulmonary vasoconstriction (HPV) maintains blood oxygenation during acute hypoxia but contributes to pulmonary hypertension during chronic hypoxia. The mechanisms of HPV remain controversial, in part because HPV is usually studied in the presence of agonist-induced preconstriction (‘pretone’...

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Autores principales: Connolly, Michelle J, Prieto-Lloret, Jesus, Becker, Silke, Ward, Jeremy P T, Aaronson, Philip I
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2013
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784194/
https://ncbi.nlm.nih.gov/pubmed/23774281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.253682
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