Altered Ca(2+) concentration, permeability and buffering in the myofibre Ca(2+) store of a mouse model of malignant hyperthermia

Malignant hyperthermia (MH) is linked to mutations in the type 1 ryanodine receptor, RyR1, the Ca(2+) channel of the sarcoplasmic reticulum (SR) of skeletal muscle. The Y522S MH mutation was studied for its complex presentation, which includes structurally and functionally altered cell ‘cores’. Imag...

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Bibliographische Detailangaben
Hauptverfasser: Manno, Carlo, Figueroa, Lourdes, Royer, Leandro, Pouvreau, Sandrine, Lee, Chang Seok, Volpe, Pompeo, Nori, Alessandra, Zhou, Jingsong, Meissner, Gerhard, Hamilton, Susan L, Ríos, Eduardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2013
Schlagworte:
Molecular and Cellular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784192/
https://ncbi.nlm.nih.gov/pubmed/23798496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.259572
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