Febuxostat, an Inhibitor of Xanthine Oxidase, Suppresses Lipopolysaccharide-Induced MCP-1 Production via MAPK Phosphatase-1-Mediated Inactivation of JNK

Excess reactive oxygen species (ROS) formation can trigger various pathological conditions such as inflammation, in which xanthine oxidase (XO) is one major enzymatic source of ROS. Although XO has been reported to play essential roles in inflammatory conditions, the molecular mechanisms underlying...

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Detaylı Bibliyografya
Asıl Yazarlar: Nomura, Johji, Busso, Nathalie, Ives, Annette, Tsujimoto, Syunsuke, Tamura, Mizuho, So, Alexander, Yamanaka, Yoshihiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783396/
https://ncbi.nlm.nih.gov/pubmed/24086554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075527
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