Anti-HIV Activity of Human Defensin 5 in Primary CD4+ T Cells under Serum-Deprived Conditions Is a Consequence of Defensin-Mediated Cytotoxicity

BACKGROUND: We have previously shown that human defensin 5 (HD5) promotes HIV infectivity in both primary CD4+ T cells and HeLa cells expressing CD4 and CCR5. HD5 is induced in response to sexually transmitted infections (STIs) such as Chlamydia trachomatis and Neisseria gonorrhoeae, suggesting it p...

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Main Authors: Ding, Jian, Tasker, Carley, Valere, Kimyata, Sihvonen, Tiina, Descalzi-Montoya, Dante B., Lu, Wuyuan, Chang, Theresa L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783372/
https://ncbi.nlm.nih.gov/pubmed/24086683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076038
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